Simultaneous in vivo pH and temperature mapping using a PARACEST-MRI contrast agent

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A Single PARACEST MRI Contrast Agent for Accurate in vivo pH Measurements

Introduction: pH is a physiological indicator of tumor lesions and other pathological abnormalities in soft tissues. MRI has shown tremendous potential for noninvasive in vivo pH measurements, though formidable challenges exist regarding sensitivity, accuracy and/or the need of a second pHunresponsive agent as control. Endogenous Chemical Exchange Saturation Transfer (CEST) and PARAmagnetic CES...

متن کامل

A novel MRI contrast agent synthesized by ion exchange method

Objective: In this study, the zeolite-coated iron oxide nanoparticles were evaluated as MRI contrast agent and effect of the nanocomposite synthesis method on MRI contrast was tested. Materials and Methods: Ion exchange method was used for synthesis of iron oxide-zeolite and the as prepared nanocomposite was characterized by XRD, FESEM and TEM. The nanocomposite toxicity in the cell culture, a...

متن کامل

Dual MRI-SPECT agent for pH-mapping.

A new dual MRI/SPECT pH-responsive agent where the SPECT active moiety acts as reporter of the concentration making it possible to exploit the responsiveness of the MRI probe.

متن کامل

A self-calibrating PARACEST MRI contrast agent that detects esterase enzyme activity.

The CEST effect of many PARACEST MRI contrast agents changes in response to a molecular biomarker. However, other molecular biomarkers or environmental factors can influence CEST, so that a change in CEST is not conclusive proof for detecting the biomarker. To overcome this problem, a second control CEST effect may be included in the same PARACEST agent, which is responsive to all factors that ...

متن کامل

CoCEST: cobalt(II) amide-appended paraCEST MRI contrast agents.

The first examples of air-stable Co(II) paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Magnetic Resonance in Medicine

سال: 2012

ISSN: 0740-3194

DOI: 10.1002/mrm.24539